Some Ideas on Superantigen Recognition and Interactions - Preprints.org You Should Know
Endogenous Droops [modify] Minor lymphocyte stimulating (Mls) exotoxins were originally discovered in the thymic stromal cells of mice. These toxic substances are encoded by SAg genes that were incorporated into the mouse genome from the mouse mammary tumour virus (MMTV). The existence of these genes in the mouse genome allows the mouse to express the antigen in the thymus as a method of negatively choosing for lymphocytes with a variable Beta region that is vulnerable to stimulation by the viral Droop.
Comparable endogenous SAg-dependent choice has yet to be determined in the human genome, however endogenous Droops have actually been found and are thought of playing an important function in viral infection. stage 1 colon cancer treatment by the Epstein, Barr virus, for instance, is known to trigger production of a SAg in infected cells, yet no gene for the toxin has actually been discovered on the genome of the virus.
Similar outcomes have been discovered with rabies, cytomegalovirus, and HIV. Referrals [modify] Llewelyn M, Cohen J (March 2002). "Superantigens: microbial agents that corrupt immunity". Lancet Infect Dis. 2 (3 ): 15662. doi:10. 1016/S1473 -3099( 02 )00222-0. PMID 11944185. Li H., Llera A., Malchiodi E.L., Mariuzza R.A. The structural basis of T cell activation by superantigens.
Rev. Immunol. 1999; 17:435466. doi: 10. 1146/annurev. immunol. 17. 1.435. Sriskandan S, Faulkner L, Hopkins P (2007 ). "Streptococcus pyogenes: Insight into the function of the streptococcal superantigens". Int. J. Biochem. Cell Biol. 39 (1 ): 129. doi:10. 1016/j. biocel. 2006. 08.009. PMID 17029999. Mehindate K, Thibodeau J, Dohlsten M, Kalland T, Skaly RP, Mourad W (November 1995).
About Superantigens Elicit “Cytokine Storm”: Responsible T-Cells
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